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Lab Safety and Security Certifications

The research laboratory of the Sailor group at UCSD adheres to all applicable University of California research safety policies and procedures, including chemical safety, chemical hygiene, hazardous waste disposal, handling of nanomaterials, occupational health, research compliance, ethical standards, and export controls as outlined (here).

o Laboratory Safety Manual (LSM) http://blink.ucsd.edu/safety/research-lab/laboratory/index.html
o Chemical Hygiene Plan (CHP) http://blink.ucsd.edu/safety/research-lab/chemical/hygiene.html
o Chemical Hazard Use Application (CHUA) https://ehs.ucsd.edu/myresearchsafety/
o Hazard Control Plans (HCPs) accessed through CHUA
o Material Safety Data Sheets https://ehs.ucsd.edu/myresearchsafety/

Safety tour and checklist for all new coworkers

Material Safety Data Sheets (MSDS) information, safety procedures for hazardous chemicals

UCSD EMERGENCY GUIDE

GENERAL LABORATORY SAFETY PROCEDURES

HYDROFLUORIC ACID HAZARDS
From the Mallincrodt Baker, Inc. MSDS:
Hazards Identification
Emergency Overview
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POISON! DANGER! CORROSIVE. EXTREMELY HAZARDOUS LIQUID AND VAPOR. CAUSES SEVERE BURNS WHICH MAY NOT BE IMMEDIATELY PAINFUL OR VISIBLE. MAY BE FATAL IF SWALLOWED OR INHALED. LIQUID AND VAPOR CAN BURN SKIN, EYES AND RESPIRATORY TRACT. CAUSES BONE DAMAGE. REACTION WITH CERTAIN METALS GENERATES FLAMMABLE AND POTENTIALLY EXPLOSIVE HYDROGEN GAS.

J.T. Baker SAF-T-DATA(tm) Ratings
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Health Rating: 4 - Extreme (Poison)
Flammability Rating: 0 - None
Reactivity Rating: 2 - Moderate
Contact Rating: 4 - Extreme (Corrosive)
Lab Protective Equip: GOGGLES & SHIELD; LAB COAT & APRON; VENT HOOD; PROPER GLOVES
Storage Color Code: White (Corrosive)
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Potential Health Effects
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Exposure to hydrofluoric acid can produce harmful health effects that may not be immediately apparent.

Inhalation:
Severely corrosive to the respiratory tract. May cause sore throat, coughing, labored breathing and lung congestion/inflammation.
Ingestion:
Corrosive. May cause sore throat, abdominal pain, diarrhea, vomiting, severe burns of the digestive tract, and kidney dysfunction.
Skin Contact:
Corrosive to the skin. Skin contact causes serious skin burns which may not be immediately apparent or painful. Symptoms may be delayed 8 hours or longer. The fluoride ion readily penetrates the skin causing destruction of deep tissue layers and even bone.
Eye Contact:
Corrosive to the eyes. Symptoms of redness, pain, blurred vision, and permanent eye damage may occur.
Chronic Exposure:
Intake of more than 6 mg of fluorine per day may result in fluorosis, bone and joint damage. Hypocalcemia and hypomagnesemia can occur from absorption of fluoride ion into blood stream.
Aggravation of Pre-existing Conditions:
Persons with pre-existing skin disorders, eye problems, or impaired kidney or respiratory function may be more susceptible to the effects of this substance.

First Aid Measures For HF contact
Inhalation:
Get medical help immediately. If patient is unconscious, give artificial respiration or use inhalator. Keep patient warm and resting, and send to hospital after first aid is complete.
Ingestion:
If swallowed, DO NOT INDUCE VOMITING. Give large quantities of water. Never give anything by mouth to an unconscious person. Get medical attention immediately.
Skin Contact:
1) Remove the victim from the contaminated area and immediately place him under a safety shower or wash him with a water hose, whichever is available.
2) Remove all contaminated clothing. Handle all HF-contaminated material with gloves made of appropriate material, such as PVC or neoprene
3) Keep washing with large amounts of water for a minimum of 15 minutes.
4) Have someone make arrangements for medical attention while you continue flushing the affected area with water.
5) If HF antidote gel (2.5% calcium gluconate in a water-soluble gel) is available, limit the washing to five minutes and massage the gel into the affected area.
6) Seek medical attention as soon as possible for all burns regardless of how minor they may appear initially.

ALTERNATIVES TO CALCIUM GLUCONATE GEL
Immerse the burned area in a solution of 0.2% iced aqueous Hyamine 1622 or 0.13% iced aqueous Zephiran Chloride. If immersion is not practical, towels should be soaked with one of the above solutions and used as compresses for the burn area. Ideally compresses should be changed every 2 minutes. Hyamine 1622 is a trade name for tetracaine benzethonium chloride, Merck Index Monograph 1078, a quaternary ammonium compound sold by Rohm & Haas, Philadelphia. Zephiran Chloride is a trade name for benzalkonium chloride, Merck Index Monograph 1059, also a quaternary ammonium compound, sold by Sanofi-Synthelabo Inc., New York, NY.
Eye Contact:
1) Irrigate eyes for at least 30 minutes with copious quantities of water, keeping the eyelids apart and away from eyeballs during irrigation.
2) Get competent medical attention immediately, preferably an eye specialist.
3) If a physician is not immediately available, apply one or two drops of ophthalmic anesthetic, (e.g., 0.5% Pontocaine Hydrochloride solution).
4) Do not use oily drops, ointment or HF skin burn treatments. Place ice pack on eyes until reaching emergency room.

Note to Physician:
General: For burns of moderate areas, (greater than 8 square inches), ingestion and significant inhalation exposure, severe systemic effects may occur, and admission to a critical care unit should be considered. Monitor and correct for hypocalcemia, cardiac arrhythmias, hypomagnesemia and hyperkalemia. In some cases renal dialysis may be indicated.

Inhalation: Treat as chemical pneumonia. Monitor for hypocalcemia, 2.5% calcium gluconate in normal saline by nebulizer or by IPPB with 100% oxygen may decrease pulmonary damage. Bronchodilators may also be administered.

Skin: For deep skin burns or contact with concentrated HF (over 50%) solution, consider infiltration about the affected area with 5% calcium gluconate [equal parts of 10% calcium gluconate and sterile saline for injection]. Burns beneath the nail may require splitting the nail and application of calcium gluconate to the exposed nail bed. For certain burns, especially of the digits, use of intra-arterial calcium gluconate may be indicated.

Eyes: Irrigation may be facilitated by use of Morgan lens or similar ocular irrigator, using 1% aqueous calcium gluconate solution [50ml of calcium gluconate 10% in 500 ml normal saline].

AN ALTERNATIVE FIRST AID PROCEDURE: The effect of HF, i.e. onset of pain, particularly in dilute solutions, may not be felt for up to 24 hours. It is important, therefore, that persons using HF have immediate access to an effective antidote even when they are away from their work place in order that first aid treatment can be commenced immediately.

We recommend that any person in contact with HF should carry, or have access to a tube of HF Antidote Gel at all times; ideally with one tube at the work place, one on the person and one at home.

It is imperative that any person who has been contaminated by HF should seek medical advice when the treatment by HF Antidote Gel has been applied.
REFERENCES:
1. Browno, T.D. Treatment of Hydrofluoric Acid Burns 2. Sprout, W.L. et al Treatment of Severe Hydrofluoric Acid Exposures (Journal of American Occupational Medicine 25:12, 1993) 3. Bracken, W.M. et al Comparative Effectiveness of Topical Treatments for Hydrofluoric Acid Burns, University of Kansas (Journal of Occupational Medicine 27:10:1985) 4. Burke, W.J. , et al Systemic Fluoride Poisoning Resulting from A Fluoride Skin Burn (Journal of Occupational Medicine (5,39:1973)

HF ANTIDOTE GEL:
Distributed by Pharmascience Inc.
8400 Darnley Rd. Montreal, Canada. H4T 1M4
Phone: ( 514 ) 340 - 1114
Fax: ( 514 ) 342 - 7764
U.S. (Buffalo, NY) distributor: 1-800-207-4477


Questions: msailor@ucsd.edu.